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August 1, 1978Clinical Science

Lack of Effect of Isometric Handgrip Exercise on the Responses of the Carotid Sinus Baroreceptor Reflex in Man

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Why the study?

Does isometric handgrip exercise alter the responses of the carotid sinus baroreceptor reflex in men?

Population

7 male volunteer subjects

Comparison

Isometric handgrip exercise at 35, 45, and 65%… vs At rest

Design

Other

Authors

JLJohn LudbrookSouth Australia PathologyIFIrwin FarisAustralian Road Research BoardJIJ. IannosRepatriation General Hospital

Discussion

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Overview

Baroreflex blunting unlikely drives pressor responses to handgrip; leaves open primary mechanisms for further study.

Key Points

  • To determine whether isometric handgrip exercise alters carotid sinus baroreceptor reflex control of arterial blood pressure and heart rate in humans.
  • Tested 7 male volunteer subjects at rest and during isometric handgrip at 35%, 45%, and 65% of maximum voluntary contraction.
  • Altered carotid sinus transmural pressure by a median of −34 mmHg and +33 mmHg using a variable-pressure neck chamber for 60 s (at 35% and 45% MVC) and 30 s (at 65% MVC).
  • Arterial blood pressure responses to alterations in carotid sinus transmural pressure showed virtually no alteration during handgrip at 35%, 45%, or 65% of maximum voluntary contraction.
  • The bradycardic response to increased carotid sinus transmural pressure was reduced at various time points after initiating handgrip at 45% and 65% of maximum voluntary contraction.

Structured PICO

Does isometric handgrip exercise alter the responses of the carotid sinus baroreceptor reflex in men?

P
Population
7 male volunteer subjects
I
Intervention
Isometric handgrip exercise at 35, 45, and 65% of maximum voluntary contraction
C
Comparator
At rest
O
Outcome
Change in arterial pressure and heart rate in response to alteration of carotid sinus transmural pressure (median -34 mmHg and +33 mmHg)surrogate

A reduction in arterial baroreceptor reflex sensitivity does not play an important role in initiating the increase in arterial blood pressure and heart rate caused by isometric exercise.

Cite This Study

Ludbrook et al. (1978) studied this question.

synapsesocial.com/papers/6a10109957bfcc72645fd191https://doi.org/10.1042/cs0550189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Isometric Hand-Grip Exercise on the Carotid Sinus Baroreceptor Reflex in Man1978 · 77 citations
  2. 2Baroreflex responsiveness is maintained during isometric exercise in humans1986 · 55 citations
  3. 3Effects of isometric exercise on the carotid baroreflex in hypertensive subjects.1982 · 15 citations
  4. 4Cardiovascular responses to carotid sinus baroreceptor stimulation during moderate to severe exercise in man1990 · 53 citations
  5. 5INTERPLAY AND INTERFERENCE OF THE CAROTID BARORECEPTORS, CENTRAL COMMAND, ERGORECEPTORS ON THE PERIPHERAL VASCULAR RESPONSES DURING STATIC EXERCISE1989 · 4 citations