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March 1, 1982HypertensionOpen Access

Effects of isometric exercise on the carotid baroreflex in hypertensive subjects.

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Why the study?

Does isometric exercise alter carotid baroreflex modulation of blood pressure and heart rate in subjects with uncomplicated untreated essential hypertension?

Population

19 subjects with uncomplicated untreated essential hypertension

Comparison

Carotid baroreceptor stimulation by neck suction… vs Carotid baroreceptor stimulation at rest

Design

Other

Authors

GMG. ManciaGeneral / Preventive / LipidsAFA FerrariUniversidade PaulistaLGL GregoriniUniversity of Milan

Discussion

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Implication

Supports preserved baroreflex BP modulation during isometric exercise in hypertension; leaves open clinical relevance of impaired HR responses.

Key Points

  • To determine whether isometric exercise blunts carotid baroreflex regulation of arterial blood pressure in hypertensive individuals, as it does for heart rate modulation.
  • Evaluated 19 subjects with uncomplicated, untreated essential hypertension.
  • Applied 30-second carotid baroreceptor stimulation via neck suction at rest and during hand-grip exercise sustained at 40% of maximal voluntary strength.
  • Recorded continuous intra-arterial blood pressure and electrocardiographic R-R interval responses.
  • Isometric hand-grip exercise diminished carotid baroreceptor-mediated prolongation of R-R intervals by 61% relative to resting conditions.
  • Carotid baroreceptor-mediated reductions in arterial blood pressure were not significantly altered during hand-grip exercise compared to rest, consistent across milder and more severe hypertension subgroups.

Structured PICO

Does isometric exercise alter carotid baroreflex modulation of blood pressure and heart rate in subjects with uncomplicated untreated essential hypertension?

P
Population
19 subjects with uncomplicated untreated essential hypertension
I
Intervention
Carotid baroreceptor stimulation by neck suction of 30 seconds' duration during hand-grip exercise performed at 40% of maximal strength
C
Comparator
Carotid baroreceptor stimulation at rest
O
Outcome
Blood pressure and R-R interval responses to baroreceptor stimulationsurrogate

Carotid baroreceptor influence on blood pressure is largely preserved during isometric exercise in hypertensive subjects, despite marked impairment of its influence on the sinus node.

Cite This Study

Mancia et al. (1982) studied this question.

synapsesocial.com/papers/6a73b5465946a55bc0fb7729https://doi.org/10.1161/01.hyp.4.2.245
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of Effect of Isometric Handgrip Exercise on the Responses of the Carotid Sinus Baroreceptor Reflex in Man1978 · 48 citations
  2. 2Comparison of the effects of exercise and posture on the baroreflex in man1971 · 39 citations
  3. 3Effect of central venous pressure on arterial baroreflex control of heart rate1979 · 61 citations
  4. 4Differentiated Interaction between the Hypothalamic Defence Reaction and Baroreceptor Reflexes1970 · 122 citations
  5. 5Baroreceptor reflexes in human hypertension.1978 · 163 citations