Incidence, predictors, and outcomes of coronary dissections left untreated after drug-eluting stent implantation†
Why the study?
Do untreated residual coronary dissections after drug-eluting stent implantation increase the risk of adverse cardiovascular events?
Population
2,418 consecutive patients (4,630 lesions) undergoing drug-eluting stent (DES) implantation
Comparison
Residual coronary dissections left untreated… vs No residual coronary dissection after DES…
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Untreated residual dissections after DES are associated with higher MACE; leaves open whether sealing improves outcomes in prospective trials.
Structured PICO
Do untreated residual coronary dissections after drug-eluting stent implantation increase the risk of adverse cardiovascular events?
P
Population
2,418 consecutive patients (4,630 lesions) undergoing drug-eluting stent (DES) implantation
I
Intervention
Residual coronary dissections left untreated after DES implantation
C
Comparator
No residual coronary dissection after DES implantation
O
Outcome
Major adverse cardiovascular events (MACE: composite of death, myocardial infarction, or target vessel revascularization) at in-hospital, 1-month, and 6-month follow-upcomposite
Untreated residual coronary dissections after DES implantation are associated with significantly worse clinical outcomes, including increased MACE and stent thrombosis, supporting the strategy of sealing dissection flaps.
Cite This Study
Biondi‐Zoccai et al. (2005) studied this question.