Why the study?
Does simvastatin reduce myocardial fibrosis and collagen I deposition in the non-infarcted region after myocardial infarction in a rat model?
Population
Rat model of myocardial infarction (MI) generated by ligating the left anterior descending coronary artery
Comparison
Simvastatin or pyrrolidine dithiocarbamate vs Vehicle (MI control group)
Design
Preclinical, Rats surviving the MI operation were randomly divided into 3 groups
Follow-up
4 weeks
Authors
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Should not change post-MI practice; hypothesis-generating for simvastatin's antifibrotic effects in humans.
Does simvastatin reduce myocardial fibrosis and collagen I deposition in the non-infarcted region after myocardial infarction in a rat model?
Simvastatin attenuates post-MI myocardial fibrosis and collagen I over-expression in the non-infarcted region, likely via inhibition of NF-κB and osteopontin up-regulation.
Zhang et al. (2010) studied this question.
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