Why the study?
Arrhythmogenic cardiomyopathy with exclusive or predominant left ventricular involvement has a heterogeneous genetic basis and broad clinical phenotypes, requiring high clinical suspicion for accurate diagnosis and genotype-based therapy to prevent sudden death.
This review highlights the heterogeneous genetic basis and clinical phenotypes of arrhythmogenic left ventricular cardiomyopathy, emphasizing the need for high clinical suspicion and genotype-based therapy to prevent sudden death.
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May prompt genotype-informed risk stratification in unexplained cardiomyopathy; leaves open prospective validation of targeted therapies.
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Torbey et al. (2023) studied this question.
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