Why the study?
Does systemic hypercapnia interact with muscle afferent activation to increase ventilation in humans?
Does systemic hypercapnia interact with muscle afferent activation to increase ventilation in humans?
Sustained elevation of ventilation during PECO in systemic but not local hypercapnia suggests a synergistic interaction between central chemoreception and muscle afferent feedback.
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Supports synergistic central chemoreception-muscle afferent interaction; extends ventilatory control models but leaves clinical translation open.
Bruce et al. (2015) studied this question.
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