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September 1, 2002Clinical Science

Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts

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Why the study?

Does fenofibrate reduce cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts?

Population

Rats with hypertrophied hearts due to pressure-overload by abdominal aortic banding (AB)

Comparison

Fenofibrate started 7 days before abdominal… vs Vehicle treatment

Design

Preclinical

Follow-up

4 days after abdominal aortic banding

Authors

TOTakehiro OgataYamagata UniversityTMTakashi MiyauchiUniversity of TsukubaSSSatoshi SakaiRyukoku University

Discussion

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Implication

Hypothesis-generating for fenofibrate in pressure-overload fibrosis; leaves open human translation and clinical relevance.

Structured PICO

Does fenofibrate reduce cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts?

P
Population
Rats with hypertrophied hearts due to pressure-overload by abdominal aortic banding (AB)
I
Intervention
Fenofibrate (80 mg/kg per day, oral) started 7 days before abdominal aortic banding
C
Comparator
Vehicle treatment
O
Outcome
mRNA levels of ET-1, collagen type I and type III, and histological features of myocardial fibrosissurrogate

Fenofibrate attenuates myocardial fibrosis and ET-1 production in pressure-overloaded rat hearts, likely through suppression of AP-1-mediated ET-1 gene augmentation.

Cite This Study

Ogata et al. (2002) studied this question.

synapsesocial.com/papers/6a10c4fd39dd87f6d0ee4eedhttps://doi.org/10.1042/cs103s284s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biochemical Correlates of Cardiac Hypertrophy: IV. OBSERVATIONS ON THE CELLULAR ORGANIZATION OF GROWTH DURING MYOCARDIAL HYPERTROPHY IN THE RAT1969 · 191 citations
  2. 2Role of Endothelin in Deterioration of Heart Failure Due to Cardiomyopathy in Hamsters1999 · 97 citations
  3. 3Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.1994 · 251 citations
  4. 4Myocardial Fibrosis in DOCA-Salt Hypertensive Rats2001 · 157 citations
  5. 5Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo1996 · 141 citations