Proarrhythmic effect of class I agents: Clinical and electrocardiographic investigation of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias.

Kiyotaka Matsuo; Takashi Kurita; Atsushi Taguchi; Wataru Shimizu; Kazuhiro Suyama; Naohiko Aihara; Shiro Kamakura; Katsuro Shimomura

doi:10.5105/jse.17.46

January 1, 1997Japanese Journal of ElectrocardiologyOpen Access

Proarrhythmic effect of class I agents: Clinical and electrocardiographic investigation of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias.

View Full Paper

Ask AI

Bookmark

Share

Why the study?

What are the clinical and electrocardiographic characteristics of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias in patients taking class Ia or Ic antiarrhythmic drugs?

Structured PICO

What are the clinical and electrocardiographic characteristics of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias in patients taking class Ia or Ic antiarrhythmic drugs?

P

Population

5 patients (2 men, 3 women, mean age 52±7 years) with underlying heart disease (hypertrophic cardiomyopathy, dilated cardiomyopathy, or post-valvular surgery) who developed polymorphic ventricular tachycardia (PVT) associated with QRS widening during atrial tachyarrhythmias while receiving class Ia or Ic antiarrhythmic drugs for paroxysmal atrial fibrillation or flutter.

I

Intervention

Class Ia or Ic antiarrhythmic drugs (pilsicainide, flecainide, disopyramide, cibenzoline) administered at normal doses.

O

Outcome

Clinical and electrocardiographic characteristics of polymorphic ventricular tachycardia (PVT) associated with QRS widening.safety

Class Ia and Ic antiarrhythmic drugs can induce polymorphic ventricular tachycardia due to rate-dependent intraventricular conduction delay (QRS widening) during atrial tachyarrhythmias in patients with underlying heart disease.

Implication

QRS monitoring may flag PVT risk with class Ia/Ic agents during atrial tachyarrhythmias; leaves open prospective validation in larger cohorts.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Matsuo et al. (1997) studied this question.

synapsesocial.com/papers/6a10d1835e6663f9d2647b98 https://doi.org/10.5105/jse.17.46

View Full Paper

Ask AI

Bookmark

Share

Proarrhythmic effect of class I agents: Clinical and electrocardiographic investigation of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias.

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Proarrhythmic effect of class I agents: Clinical and electrocardiographic investigation of polymorphic ventricular tachycardia associated with QRS widening during atrial tachyarrhythmias.

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading