Why the study?
What are the clinical characteristics and risk factors for Torsades de pointes and incessant ventricular tachycardia induced by antiarrhythmic agents?
What are the clinical characteristics and risk factors for Torsades de pointes and incessant ventricular tachycardia induced by antiarrhythmic agents?
Proarrhythmic effects of antiarrhythmic agents manifest distinctly as TdP (associated with female sex, hypokalemia, and QTc prolongation) and incessant VT (associated with underlying reentrant VT and significant QRS prolongation).
May inform distinct risk stratification for TdP versus incessant VT on antiarrhythmics; leaves open causal validation in randomized settings.
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Kurita et al. (1993) studied this question.
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