Key result
Antiarrhythmic drugs paradoxically accelerate ventricular tachycardia rate by ~55%, triggering severe symptoms.
Why the study?
Some antiarrhythmic agents that reduce ventricular tachycardia rate may paradoxically cause heart rate acceleration during treatment, with unclear mechanisms.
Case Report (n=6)
No
Absolute Event Rate: 201% vs 130%
p-value: p=<0.01
Caution against antiarrhythmic use in VT without close monitoring; leaves open mechanisms of paradoxical acceleration in prospective studies.
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Shinichi Niwano (1987) conducted a case report in Sustained ventricular tachycardia (n=6). Antiarrhythmic drugs (e.g., procainamide, disopyramide) vs. Drug-controlled baseline was evaluated on Ventricular tachycardia heart rate during acceleration (p=<0.01). Administration of antiarrhythmic drugs paradoxically accelerated ventricular tachycardia heart rate from a controlled 130±17/min to 201±18/min (P<0.01), resulting in severe clinical symptoms.
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