August 23, 2013Platelets
Predictive values of post-clopidogrel platelet reactivity assessed by different platelet function tests on ischemic events in East Asian patients treated with PCI
Key result
Platelet reactivity measured by LTA and VerifyNow significantly discriminated the risk of 30-day ischemic events (15.8% overall rate) after PCI (all p<0.001), whereas MEA did not (p>0.05).
Why the study?
Do different platelet function tests (LTA, VerifyNow, MEA) predict 30-day ischemic events in Korean patients receiving clopidogrel prior to PCI?
Population
n=228 Korean patients receiving clopidogrel prior to undergoing percutaneous coronary intervention (PCI)
Design
Cohort
Follow-up
30-day
Authors
Discussion
Loading...
Member takes
Implication
LTA and VerifyNow may aid 30-day risk stratification after PCI in East Asians on clopidogrel; leaves open whether MEA or routine testing should change practice.
Study Design
Type
Observational (n=228)
Structured PICO
Do different platelet function tests (LTA, VerifyNow, MEA) predict 30-day ischemic events in Korean patients receiving clopidogrel prior to PCI?
P
Population
n=228 Korean patients receiving clopidogrel prior to undergoing percutaneous coronary intervention (PCI)
I
Intervention
Platelet reactivity assessment using light transmittance aggregometry (LTA), VerifyNow P2Y12 assay, and multiple electrode platelet aggregometry (MEA)
O
Outcome
30-day occurrence of ischemic events after PCIcomposite
LTA and VerifyNow assays, but not MEA, effectively discriminate the risk of 30-day ischemic events after PCI in East Asian patients on clopidogrel, with predictive cut-offs depending on sampling time.
Cite This Study
Zhang et al. (2013) conducted an observational in Patients undergoing PCI (n=228). Platelet function measurement assays (LTA, VerifyNow, MEA) was evaluated on 30-day occurrence of ischemic events after PCI. Platelet reactivity measured by LTA and VerifyNow significantly discriminated the risk of 30-day ischemic events (15.8% overall rate) after PCI (all p<0.001), whereas MEA did not (p>0.05).