Key result
Von Willebrand disease linked to ~19% lower risk of CVA.
Why the study?
It remained unclear whether Von Willebrand disease is associated with a decreased risk of developing cerebrovascular accident.
Does Von Willebrand disease reduce the risk of cerebrovascular accident?
Population
Patients in the National Inpatient Sample from 2009 to 2014
Comparison
Patients with vWD vs patients without vWD
Design
Retrospective database study
Authors
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May suggest protective effect of von Willebrand factor deficiency against cerebrovascular accident; leaves open causality and requires prospective confirmation.
Observational
Yes
Does Von Willebrand disease reduce the risk of cerebrovascular accident?
Effect estimate: Adjusted RR 0.81 (95% CI 0.76-0.86)
Absolute Event Rate: 1.31% vs 2.04%
Von Willebrand disease is associated with a lower relative risk of developing cerebrovascular accident, suggesting that deficiency of Von Willebrand factor may be protective against CVA.
Olagunju et al. (2023) conducted an observational in Von Willebrand disease. Von Willebrand disease vs. Patients without Von Willebrand disease was evaluated on Cerebrovascular accident (Adjusted RR 0.81, 95% CI 0.76-0.86). Von Willebrand disease was associated with a lower risk of cerebrovascular accident compared to patients without the disease (1.31% vs 2.04%; adjusted RR 0.81; 95% CI 0.76-0.86).
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