Key result
Baseline plasma fibrinogen was independently associated with an increased risk of stroke (RR 1.52; 95% CI 1.17-1.98) after adjusting for conventional risk factors.
Why the study?
Do hemostatic factors predict the incidence of ischemic heart disease and stroke in older adults?
Population
1592 men and women aged 55 to 74 years, randomly sampled from the general population (Edinburgh Artery study)
Design
Cohort
Follow-up
5 years
Authors
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May support risk stratification in older adults; hypothesis-generating for causal role and interventions.
Cohort (n=1,592)
Do hemostatic factors predict the incidence of ischemic heart disease and stroke in older adults?
Effect estimate: RR 1.52 (95% CI 1.17-1.98)
Increased coagulation activity and disturbed fibrinolysis, specifically elevated fibrinogen, TPA antigen, and D-dimer, are independent predictors of future IHD and stroke in older adults.
Smith et al. (1997) conducted a cohort in Ischemic heart disease and stroke (n=1,592). Hemostatic factors (plasma fibrinogen, TPA antigen, fibrin D-dimer) was evaluated on Fatal and nonfatal ischemic heart disease and stroke events (RR 1.52, 95% CI 1.17-1.98). Baseline plasma fibrinogen was independently associated with an increased risk of stroke (RR 1.52; 95% CI 1.17-1.98) after adjusting for conventional risk factors.
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