Fibrinogen Concentration and Risk of Ischemic Stroke and Acute Coronary Events in 5113 Patients With Transient Ischemic Attack and Minor Ischemic Stroke
Why the study?
Does higher fibrinogen concentration predict recurrent ischemic stroke and acute coronary events in patients with recent TIA or minor ischemic stroke?
Population
5113 patients with recent transient ischemic attack or minor ischemic stroke from 3 prospective studies.
Comparison
Higher fibrinogen concentration vs Lower fibrinogen concentration
Design
Cohort
Follow-up
23,272 patient-years
Authors
Discussion
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Member takes
Implication
Higher fibrinogen may aid post-TIA risk stratification; leaves open utility for guiding therapy or as intervention target.
Structured PICO
Does higher fibrinogen concentration predict recurrent ischemic stroke and acute coronary events in patients with recent TIA or minor ischemic stroke?
P
Population
5113 patients with recent transient ischemic attack (TIA) or minor ischemic stroke from 3 prospective studies (UK-TIA trial n=1860, Dutch TIA trial n=2960, Oxford TIA Study n=293).
I
Intervention
Higher fibrinogen concentration (values above the median)
C
Comparator
Lower fibrinogen concentration (values below the median)
O
Outcome
Ischemic strokehard clinical
In patients with previous TIA or minor ischemic stroke, higher fibrinogen levels independently predict recurrent ischemic stroke and acute coronary events.
Cite This Study
Rothwell et al. (2004) studied this question.