Why the study?
Does higher fibrinogen increase the risk of incident coronary events in patients with known cerebrovascular disease, and is this modified by age and glycaemic control?
Does higher fibrinogen increase the risk of incident coronary events in patients with known cerebrovascular disease, and is this modified by age and glycaemic control?
The association between fibrinogen and risk of acute coronary events is strongest in younger patients with normal glucose levels, supporting a causal role mediated by fibrin clot permeability.
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May refine coronary risk stratification in younger cerebrovascular patients; hypothesis-generating for fibrinogen as causal mediator.
Howard et al. (2007) studied this question.
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