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August 23, 1984New England Journal of Medicine

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

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Why the study?

Is elevated fibrinogen level a risk factor for stroke and myocardial infarction in 54-year-old men?

Population

792 men 54 years of age

Design

Cohort

Follow-up

13.5 years

Authors

LWLars WilhelmsenUniversity of Toledo Medical CenterKSKurt SvärdsuddGeneral / Preventive / LipidsKKK Korsan-BengtsenKarolinska Institutet

Discussion

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Implication

Elevated fibrinogen may refine stroke risk assessment in middle-aged men; leaves open incremental value and need for interventional trials.

Key Points

  • This study investigates the relationship between fibrinogen levels and cardiovascular events such as stroke and myocardial infarction.
  • Analyzed plasma levels of coagulation factors, blood pressure, serum cholesterol, and smoking in 792 men aged 54.
  • Conducted follow-up over 13.5 years to document incidents of myocardial infarction and stroke.
  • Myocardial infarction occurred in 92 men and stroke in 37 during the follow-up period.
  • Fibrinogen level was identified as a significant risk factor for both myocardial infarction and stroke, even when controlling for other variables.
  • The correlation between fibrinogen and these cardiovascular events weakened but remained significant for stroke when accounting for blood pressure, serum cholesterol, and smoking.

Structured PICO

Is elevated fibrinogen level a risk factor for stroke and myocardial infarction in 54-year-old men?

P
Population
792 men 54 years of age
I
Intervention
Plasma levels of fibrinogen (exposure)
O
Outcome
Myocardial infarction and strokehard clinical

Elevated baseline fibrinogen levels are associated with an increased risk of stroke and myocardial infarction over 13.5 years of follow-up in middle-aged men.

Limitations

  • Causality cannot be inferred from these data

Cite This Study

Wilhelmsen et al. (1984) studied this question.

synapsesocial.com/papers/6a10e7be2c0ee39daeee4e15https://doi.org/10.1056/nejm198408233110804
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