Key result
Aldosterone-to-direct renin concentration ratio (ADRR) showed high diagnostic accuracy for primary aldosteronism with an optimal cutoff of 2.93, yielding 80.33% sensitivity and 92.11% specificity.
Why the study?
ADRR calculated from direct renin concentration via CLIA was proposed to replace traditional RIA-derived ARR for primary aldosteronism screening, but its diagnostic accuracy and cutoff value needed estimation.
Does ADRR measured by CLIA provide accurate diagnostic screening for primary aldosteronism compared to traditional ARR by RIA in hypertensive patients?
Observational (n=450)
No
Does ADRR measured by CLIA provide accurate diagnostic screening for primary aldosteronism compared to traditional ARR by RIA in hypertensive patients?
Absolute Event Rate: 80.33% vs 76.92%
ADRR measured by CLIA has high sensitivity and specificity for screening primary aldosteronism, supporting its use as an alternative to traditional ARR by RIA in daily practice.
May support ADRR by CLIA for PA screening in hypertension; leaves open prospective validation versus traditional ARR by RIA.
OBJECTIVES: Aldosterone-to-plasma renin activity ratio (ARR) derived from traditional radioimmunoassay (RIA) is widely used to detect primary aldosteronism (PA). Recently, aldosterone-to-direct renin concentration ratio (ADRR), which is calculated by direct renin concentration (DRC) measured by chemiluminescent immunoassay (CLIA), is proposed to replace ARR as the screening test method for PA. The purpose of the present study was to estimate the diagnostic accuracy and cutoff value of ADRR as screening test for PA. METHODS: 450 hypertensive patients with suspected PA referred to hypertension center of our department were enrolled and underwent screening and confirmatory tests of PA. Plasma renin activity (PRA), DRC, and plasma aldosterone concentration (PAC) were measured by both RIA and CLIA simultaneously during screening and confirmatory test. RESULTS: 386 patients were diagnosed as primary hypertension (PH) and 64 patients as PA. Within-patient correlation between PRA and DRC (r=0.88, P<0.001) and correlation between PAC measured by RIA and CLIA were high (r=0.80, P<0.001). The optimal cutoff value of ADRR was 2.93 (ng/dL)/(mU/L), sensitivity 80.33%, and specificity 92.11%. The optimal cutoff value of ARR was 25.28 (ng/dL)/(ng/mL/h), sensitivity 76.92%, and specificity 93.38%. CONCLUSION: The optimal cutoff values of ADRR and ARR for screening PA are defined in this patient cohort with high sensitivity and specificity. Our results are of clinical importance for accelerating the extensive use of ADRR as a screening test for PA in daily practice.
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Li et al. (2019) conducted an observational in Hypertension with suspected primary aldosteronism (n=450). Aldosterone-to-direct renin concentration ratio (ADRR) by CLIA vs. Aldosterone-to-plasma renin activity ratio (ARR) by RIA was evaluated on Diagnostic accuracy (sensitivity) for screening primary aldosteronism. Aldosterone-to-direct renin concentration ratio (ADRR) showed high diagnostic accuracy for primary aldosteronism with an optimal cutoff of 2.93, yielding 80.33% sensitivity and 92.11% specificity.
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