Key result
Corrected isocapnic buffering phase duration was significantly associated with peak VO2 (p < 0.001), indicating it is a useful measure of endurance performance in patients with coronary artery disease.
Why the study?
Is the isocapnic buffering phase duration associated with peak oxygen consumption and other cardiopulmonary parameters in patients with coronary artery disease?
Observational (n=62)
No
Is the isocapnic buffering phase duration associated with peak oxygen consumption and other cardiopulmonary parameters in patients with coronary artery disease?
p-value: p=<0.001
The isocapnic buffering phase duration during cardiopulmonary exercise testing is a useful indicator of peripheral cardiopulmonary function and endurance in patients with coronary artery disease.
May support CPET endurance assessment in CAD; leaves open prospective validation before clinical adoption.
Objectives: The significance of the isocapnic buffering (IB) phase – the period between the first ventilatory threshold (1st VT) and respiratory compensation point (RCP) – has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in patients with coronary artery disease (CAD).Methods: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010 – 2014. According to their physical conditions, the patients performed incremental cardiopulmonary exercise test (CPET) using a cycle ergometer by the ramp of 5–20 W/min. Correlations between the corrected IB phase duration and age, body mass index (BMI), left ventricular ejection fraction (LVEF), and CPET parameters were evaluated using Pearson correlation coefficients. Variables predicting peak oxygen consumption (VO2) were evaluated using multiple regression.Results: Peak VO2 (p < 0.001), VO2 at RCP (p < 0.001), ∆O2/∆WR slope (p < 0.001), maximal partial pressure of end tidal CO2 (PetCO2) (p = 0.0012), VE/VCO2 slope (p = 0.010), BMI (p = 0.012), and age (p = 0.017) were significantly correlated, whereas LVEF (p = 0.246) and VO2 at 1st VT (p = 0.179) were not significantly correlated with the corrected IB phase duration. In multiple regression analysis, the corrected IB phase duration, VO2 at 1st VT, and ∆O2/∆WR slope were significantly associated with peak VO2.Conclusion: The findings indicate that the IB phase duration is a useful indicator of peripheral cardiopulmonary function and endurance performance in CAD patients. These findings could assist the exercise prescription of cardiac rehabilitation for patients with CAD.
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Yen et al. (2018) conducted an observational in Coronary artery disease (CAD) (n=62). Cardiopulmonary exercise test (CPET) was evaluated on Correlation between corrected isocapnic buffering (IB) phase duration and peak oxygen consumption (VO2) (p=<0.001). Corrected isocapnic buffering phase duration was significantly associated with peak VO2 (p < 0.001), indicating it is a useful measure of endurance performance in patients with coronary artery disease.
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