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This research aims to assess growth hormone metabolic clearance, integrated concentrations, and production rates, particularly focusing on the influence of prednisone.

December 1, 1972Journal of Clinical InvestigationOpen Access

Growth Hormone: Metabolic Clearance Rates, Integrated Concentrations, and Production Rates in Normal Adults and the Effect of Prednisone

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This research aims to assess growth hormone metabolic clearance, integrated concentrations, and production rates, particularly focusing on the influence of prednisone.
Utilized a constant withdrawal pump to measure integrated concentrations of growth hormone (ICGH).
Calculated metabolic clearance rates (MCR) and growth hormone production rates (GHPR) in various groups of normal adults.
Compared hormonal metrics among normal females, postmenopausal females, males, and acromegalic patients, with and without prednisone administration.
Mean ICGH for premenopausal females not on medication was significantly lower than those on oral contraceptives (P < 0.005).
Growth hormone production rates varied among groups, with normal females showing a rate of 0.52 mg/24 hr per m², significantly less than those on contraceptives (1.65 mg/24 hr per m², P < 0.005).
Prednisone administration significantly decreased both ICGH and GHPR, indicating its role in inhibiting growth hormone release.

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Implication

Randomized trial evaluates growth hormone metrics in adults, highlighting prednisone's impact.

Cite This Study

Thompson et al. (1972) studied this question.

synapsesocial.com/papers/6a11c7b3a84ddbb210fd3648 https://doi.org/10.1172/jci107146

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Growth Hormone: Metabolic Clearance Rates, Integrated Concentrations, and Production Rates in Normal Adults and the Effect of Prednisone

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Discussion

Implication

Cite This Study

Growth Hormone: Metabolic Clearance Rates, Integrated Concentrations, and Production Rates in Normal Adults and the Effect of Prednisone

Key Points

Discussion

Implication

Cite This Study

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