May 1, 1996Journal of Hypertension
Association of angiotensin converting enzyme activity and arterial blood pressure in a population-based sample
Why the study?
Is circulating angiotensin converting enzyme activity associated with arterial blood pressure in middle-aged subjects?
Population
646 middle-aged subjects from a population-based sample. Subgroups analyzed included untreated men and…
Comparison
Circulating angiotensin converting enzyme activity vs Lower quartiles of circulating angiotensin…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
ACE activity-BP association appears confined to untreated men; leaves open causal and therapeutic implications in hypertension.
Structured PICO
Is circulating angiotensin converting enzyme activity associated with arterial blood pressure in middle-aged subjects?
P
Population
646 middle-aged subjects from a population-based sample. Subgroups analyzed included untreated men (n=230) and untreated women (n=264). Exclusions for primary analysis: subjects taking antihypertensive medication and those with electrocardiographic evidence of myocardial infarction.
I
Intervention
Circulating angiotensin converting enzyme (ACE) activity (highest quartile)
C
Comparator
Lower quartiles of circulating angiotensin converting enzyme (ACE) activity
O
Outcome
Arterial blood pressure (systolic and diastolic)surrogate
Higher circulating ACE activity is independently associated with elevated systolic and diastolic blood pressure in middle-aged men, but not in women.
Cite This Study
Schunkert et al. (1996) studied this question.