Why the study?
Does the ACE gene I/D polymorphism associate with coronary artery disease in subjects from the Caerphilly Heart Study?
Does the ACE gene I/D polymorphism associate with coronary artery disease in subjects from the Caerphilly Heart Study?
The DD genotype of the ACE gene may confer risk of coronary artery disease in subjects previously unidentifiable with classic risk factors, though the overall risk in the general male population may be small.
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DD genotype may flag CAD risk missed by classic factors in lower-TC/HDL men; hypothesis-generating and needs replication before any clinical use.
Mattu et al. (1995) studied this question.
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