Key result
36-hour sleep deprivation links to decreased nucleus accumbens and inferior frontal gyrus functional connectivity.
Why the study?
Few studies have examined the mechanisms underlying communication within brain networks or alterations during emotional deterioration after sleep deprivation.
Does 36 hours of total sleep deprivation reduce functional connectivity in the reward network in healthy male university students?
Observational (n=26)
Yes
Does 36 hours of total sleep deprivation reduce functional connectivity in the reward network in healthy male university students?
Total sleep deprivation decreases functional connectivity within the reward network, which correlates with enhanced negative emotional experiences.
Answers are grounded in this paper and cite their sources.
May link acute sleep loss to reward-circuit changes and negative affect; hypothesis-generating and requires validation before clinical relevance.
Sleep deprivation (SD) induces a negative emotional experience due to a prolonged time spent awake. However, few studies have focused on the mechanism underlying communication within brain networks or alterations during this emotional deterioration. We propose that negative reward judgment is important in poor emotional processing after SD, which will be reflected in functional connectivity in the reward network. We sought to analyze alterations in functional connectivity within the reward network and cerebral cortex. Furthermore, we analyzed changes in functional connectivity correlation with negative emotional experience after SD. Twenty-six healthy volunteers participated in this study. Two resting-state fMRI scans were obtained from the participants, once during resting wakefulness, and once after 36 h of total SD. The bilateral nucleus accumbens (NAc) was selected as a seed region for region of interest (ROI)-to-ROI functional connectivity analysis. Correlation analyses between functional connectivity alterations within the reward network and negative emotional experience were also performed. We found that SD decreased functional connectivity between the left NAc and anterior cingulate cortex (ACC) compared with resting wakefulness. There was a decreased functional connectivity with the ACC and right inferior frontal gyrus (IFG) after SD in the right NAc. Furthermore, decreased functional connectivity between the right NAc and right IFG, and NAc and ACC was negatively correlated with emotional experience scores. Sleep deprivation decreased functional connectivity within the reward network. This may be associated with the enhanced negative emotional experience that was found after total sleep deprivation.
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Zhang et al. (2021) conducted an observational in Healthy volunteers (n=26). Total sleep deprivation vs. Rested wakefulness was evaluated on Functional connectivity between left nucleus accumbens and right inferior frontal gyrus (p=0.0002). Total sleep deprivation for 36 hours significantly decreased functional connectivity between the left nucleus accumbens and right inferior frontal gyrus compared to rested wakefulness.
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