Randomized, Double‐Blind, Crossover Comparison of Amlodipine and Valsartan in African‐Americans with Hypertension Using 24‐Hour Ambulatory Blood Pressure Monitoring

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Hypertension (n=20). Intervention: Amlodipine vs. Valsartan 80 or 160 mg/day. Primary outcome: Achievement of goal blood pressure (≤140/90 mm Hg) (p=0.62).

Stephanie Maciejewski; Syed M. Mohiuddin; Kathleen A. Packard; Aryan N. Mooss; Antonio P. Reyes; Arash Aryana; Daniel E. Hilleman

doi:10.1592/phco.26.7.889

June 27, 2006Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Randomized, Double‐Blind, Crossover Comparison of Amlodipine and Valsartan in African‐Americans with Hypertension Using 24‐Hour Ambulatory Blood Pressure Monitoring

View Full Paper

Ask AI

Bookmark

Share

Key result

Amlodipine and valsartan produced similar rates of goal blood pressure achievement (75% vs 70%, p=0.62) in African-American patients with uncomplicated hypertension.

Why the study?

Does amlodipine compared to valsartan improve blood pressure reduction in African-American patients with uncomplicated hypertension?

Study Design

Type

RCT (n=20)

Blinding

Double-blind

Randomization

Crossover

Multicenter

No

Structured PICO

Does amlodipine compared to valsartan improve blood pressure reduction in African-American patients with uncomplicated hypertension?

P

Population

n=20 African-American patients (12 men, 8 women) with a history of uncomplicated hypertension (blood pressure > 140/90 mm Hg).

I

Intervention

Amlodipine 5 or 10 mg/day for 8-10 weeks, titrated to achieve BP ≤140/90 mm Hg, with hydrochlorothiazide 12.5 mg/day added if uncontrolled.

C

Comparator

Valsartan 80 or 160 mg/day for 8-10 weeks, titrated to achieve BP ≤140/90 mm Hg, with hydrochlorothiazide 12.5 mg/day added if uncontrolled.

O

Outcome

Blood pressure reduction measured by 24-hour ambulatory blood pressure monitoring (ABPM) and achievement of goal blood pressure (≤140/90 mm Hg).surrogate

Main Result

Absolute Event Rate: 75% vs 70%

p-value: p=0.62

Amlodipine and valsartan demonstrated comparable efficacy in reducing blood pressure in African-American patients with uncomplicated hypertension.

Implication

Either agent is appropriate initially; confirms comparable efficacy in African-American patients with uncomplicated hypertension.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Maciejewski et al. (2006) conducted an RCT in Hypertension (n=20). Amlodipine vs. Valsartan 80 or 160 mg/day was evaluated on Achievement of goal blood pressure (≤140/90 mm Hg) (p=0.62). Amlodipine and valsartan produced similar rates of goal blood pressure achievement (75% vs 70%, p=0.62) in African-American patients with uncomplicated hypertension.

synapsesocial.com/papers/6a11cdbd054dd93c545627cc https://doi.org/10.1592/phco.26.7.889

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Share

Randomized, Double‐Blind, Crossover Comparison of Amlodipine and Valsartan in African‐Americans with Hypertension Using 24‐Hour Ambulatory Blood Pressure Monitoring

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

Topics

Randomized, Double‐Blind, Crossover Comparison of Amlodipine and Valsartan in African‐Americans with Hypertension Using 24‐Hour Ambulatory Blood Pressure Monitoring

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

Keep reading

Topics

Keep reading