Why the study?
Does valsartan reduce blood pressure as effectively as amlodipine in adult outpatients with mild to moderate hypertension?
Population
168 adult outpatients with mild to moderate hypertension
Comparison
Valsartan 80 mg for 12 weeks vs Amlodipine 5 mg for 12 weeks
Design
RCT, Randomly allocated in equal number, Double-blind fashion
Follow-up
12 weeks
Authors
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Valsartan matches amlodipine for diastolic BP reduction in mild-moderate hypertension; confirms comparable efficacy in this RCT.
Does valsartan reduce blood pressure as effectively as amlodipine in adult outpatients with mild to moderate hypertension?
Valsartan 80 mg is as effective as amlodipine 5 mg in lowering blood pressure in mild to moderate hypertension, with a lower incidence of dependent edema.
Corea et al. (1996) studied this question.
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