Why the study?
Does valsartan improve blood pressure reduction and response rate compared to losartan and placebo in adults with uncomplicated essential hypertension?
Population
Adults with uncomplicated essential hypertension
Comparison
Valsartan 80 mg once daily, doubled to 160 mg… vs Losartan 50 mg once daily or placebo once daily
Design
RCT, randomized
Follow-up
8 weeks
Authors
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May support preferring valsartan over losartan for higher response rates; extends head-to-head ARB data in essential hypertension.
Does valsartan improve blood pressure reduction and response rate compared to losartan and placebo in adults with uncomplicated essential hypertension?
Valsartan 80/160 mg is as effective as losartan 50/100 mg in reducing blood pressure but yields a significantly higher responder rate at 8 weeks in patients with mild to moderate essential hypertension.
Thomas Hedner (1999) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: