What question did this study set out to answer?

To compare the antihypertensive efficacy and tolerability of once-daily irbesartan versus losartan in patients with mild-to-moderate hypertension.

April 1, 1998American Journal of HypertensionOpen Access

Comparative Efficacy of Two Angiotensin II Receptor Antagonists, Irbesartan and Losartan, in Mild-to-Moderate Hypertension

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Why the study?

Does irbesartan reduce blood pressure more than losartan in patients with mild-to-moderate hypertension?

Population

567 patients with mild-to-moderate hypertension

Comparison

Irbesartan 150 mg or 300 mg once-daily for 8 weeks vs Losartan 100 mg once-daily or placebo for 8 weeks

Design

RCT, 1:1:1:1, double-blind

Follow-up

8 weeks

Authors

KKKenneth Kassler-TaubLexicon Pharmaceuticals (United States)

Discussion

Member takes

Implication

300 mg irbesartan yields greater BP reductions than 100 mg losartan; extends head-to-head ARB efficacy data in mild-to-moderate hypertension.

Key Points

To compare the antihypertensive efficacy and tolerability of once-daily irbesartan versus losartan in patients with mild-to-moderate hypertension.
Following a placebo lead-in, 567 patients were randomized (1:1:1:1) to once-daily therapy with placebo, 100 mg losartan, 150 mg irbesartan, or 300 mg irbesartan for 8 weeks in a double-blind design.
Primary evaluations measured reductions from baseline in trough seated diastolic blood pressure (SeDBP) and seated systolic blood pressure (SeSBP), alongside monitoring of adverse events.
After 8 weeks, 300 mg irbesartan produced significantly greater reductions in trough SeDBP (by 3.0 mm Hg, P < .01) and SeSBP (by 5.1 mm Hg, P < .01) compared with 100 mg losartan, with significantly greater SeDBP reductions also present at week 1 (P < .01) and week 4 (P = .017).
Throughout the 8-week study, the antihypertensive efficacy of 150 mg irbesartan did not differ significantly from 100 mg losartan.
All treatments were well tolerated, with the 300 mg irbesartan group reporting the lowest incidence of adverse events and adverse event-related discontinuations.

Structured PICO

Does irbesartan reduce blood pressure more than losartan in patients with mild-to-moderate hypertension?

Population

567 patients with mild-to-moderate hypertension

Intervention

Irbesartan 150 mg or 300 mg once-daily for 8 weeks

Comparator

Losartan 100 mg once-daily or placebo for 8 weeks

Outcome

Reductions from baseline in trough seated diastolic blood pressure (SeDBP) and trough seated systolic blood pressure (SeSBP) at 8 weekssurrogate

Irbesartan 300 mg once-daily provides significantly greater blood pressure reduction than losartan 100 mg once-daily in patients with mild-to-moderate hypertension.

Cite This Study

Kenneth Kassler-Taub (1998) studied this question.

synapsesocial.com/papers/6a6fbb5326a7f98052dc5696 https://doi.org/10.1016/s0895-7061(97)00491-3

Topics

Hypertension management

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Implication

300 mg irbesartan yields greater BP reductions than 100 mg losartan; extends head-to-head ARB efficacy data in mild-to-moderate hypertension.

Comparative Efficacy of Two Angiotensin II Receptor Antagonists, Irbesartan and Losartan, in Mild-to-Moderate Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Comparative Efficacy of Two Angiotensin II Receptor Antagonists, Irbesartan and Losartan, in Mild-to-Moderate Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider