Key result
Hybrid Convergent procedure cuts 12-month arrhythmia recurrence ~35% vs catheter ablation in persistent AF.
Why the study?
Treatment gaps remain in AF, including the creation of durable lesions outside the pulmonary veins and effective treatment of longstanding persistent AF.
Does the hybrid convergent procedure improve outcomes in patients with persistent and long-standing persistent atrial fibrillation?
Does the hybrid convergent procedure improve outcomes in patients with persistent and long-standing persistent atrial fibrillation?
Absolute Event Rate: 67.7% vs 50%
p-value: p=0.036
This review summarizes recent data, including the CONVERGE trial, on the hybrid convergent procedure for treating persistent and long-standing persistent atrial fibrillation.
May support hybrid convergent ablation in persistent AF; leaves open need for confirmatory RCTs on durability and safety.
Recent advances have been made in AF treatment, including the role of early rhythm control and landmark clinical trials using ablation therapy. However, some treatment gaps remain, including the creation of durable lesions outside the pulmonary veins and effective treatment of longstanding persistent AF. A novel epicardial-endocardial ablation approach - the hybrid convergent procedure - was developed to combine surgical and catheter ablation techniques into a collaborative, multidisciplinary approach to managing AF. In this review, the authors discuss recently published data on hybrid convergent ablation, including results of the CONVERGE clinical trial, in the context of current challenges to treatment of persistent and long-standing persistent AF. The review also aims to provide perspective on outstanding questions and future directions in this area.
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DeLurgio et al. (2021) conducted a review in Persistent and long-standing persistent atrial fibrillation (n=153). Hybrid Convergent procedure vs. Endocardial catheter ablation was evaluated on Freedom from AF/AFL/AT absent new AADs or increased dose of previously failed AADs at 12 months (p=0.036). The Hybrid Convergent procedure significantly improved 12-month freedom from atrial arrhythmias compared to endocardial catheter ablation (67.7% vs 50.0%) in patients with persistent and long-standing persistent atrial fibrillation.
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