Key result
Left atrial voltage-based substrate modification after PVI in persistent AF patients with low-voltage zones improved freedom from recurrence compared to PVI alone (72% vs 38%, P<0.001).
Why the study?
Does LVZ-based substrate modification after PVI reduce recurrence of atrial fibrillation in patients with persistent AF and low-voltage zones?
Population
117 patients with persistent atrial fibrillation, including 55 with low-voltage zones and 62 without LVZs.
Comparison
Ablation of the entire low-voltage zone area… vs Pulmonary vein isolation alone with no further…
Design
Cohort
Follow-up
18 ± 7 months; 32 ± 7 months
Authors
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May support LVZ ablation in persistent AF with low-voltage zones; hypothesis-generating and requires randomized confirmation.
Cohort (n=117)
Does LVZ-based substrate modification after PVI reduce recurrence of atrial fibrillation in patients with persistent AF and low-voltage zones?
Absolute Event Rate: 72% vs 38%
p-value: p=<0.001
Targeted ablation of low-voltage zones in addition to pulmonary vein isolation significantly improves freedom from atrial fibrillation recurrence in patients with persistent AF and fibrotic substrates.
Yamaguchi et al. (2016) conducted a cohort in Persistent Atrial Fibrillation (n=117). LVZ-based substrate modification after PVI vs. PVI alone was evaluated on No recurrence of atrial fibrillation (p=<0.001). Left atrial voltage-based substrate modification after PVI in persistent AF patients with low-voltage zones improved freedom from recurrence compared to PVI alone (72% vs 38%, P<0.001).
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