Key result
A modified programmed electrical stimulation protocol with up to 10 extrastimuli increased the induction of ventricular arrhythmias to 50% compared to 0% with conventional protocols in wildtype mice.
Why the study?
Does a modified PES protocol with 3 to 10 extrastimuli improve the induction of ventricular arrhythmias in anesthetized wildtype mice compared to conventional PES?
Population
Anesthetized wildtype mice (C57BL/6J, n = 12)
Comparison
Modified programmed electrical stimulation… vs Conventional PES protocol using up to 3…
Design
Preclinical
Authors
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Improves VA induction rates in wildtype mice; leaves open standardization of PES protocols in preclinical arrhythmia models.
Does a modified PES protocol with 3 to 10 extrastimuli improve the induction of ventricular arrhythmias in anesthetized wildtype mice compared to conventional PES?
Absolute Event Rate: 50% vs 0%
p-value: p=0.0002
A modified programmed electrical stimulation protocol using 3 to 10 extrastimuli significantly increases the induction of ventricular arrhythmias in wildtype mice compared to conventional methods.
Clasen et al. (2018) studied Ventricular arrhythmias (n=12). Modified programmed electrical stimulation (miniburst) vs. Conventional programmed electrical stimulation (up to 3 extrastimuli) was evaluated on Ventricular arrhythmia inducibility (p=0.0002). A modified programmed electrical stimulation protocol with up to 10 extrastimuli increased the induction of ventricular arrhythmias to 50% compared to 0% with conventional protocols in wildtype mice.
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