Why the study?
Is sequential programmed electrical stimulation via a subdiaphragmatic approach feasible and reproducible for evaluating ventricular refractoriness and arrhythmia induction in mice?
Population
36 wild-type mice and a genetically modified strain (connexin43 conditional knockout mouse)
Comparison
Programmed electrical stimulation via a… vs Initial vs follow-up trials
Design
Preclinical
Follow-up
7 days
Authors
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Enables serial VERP assessment in mice; leaves open translation to clinical arrhythmia evaluation.
Is sequential programmed electrical stimulation via a subdiaphragmatic approach feasible and reproducible for evaluating ventricular refractoriness and arrhythmia induction in mice?
A novel subdiaphragmatic approach allows for feasible and reproducible sequential programmed electrical stimulation in mice to evaluate electrophysiological changes and arrhythmia risk.
Gutstein et al. (2003) studied this question.
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