Key result
Heart failure with preserved ejection fraction was twice as common in presumptive non-cardiac dyspnea compared to cardiac dyspnea (71% vs 34%, p<0.0001), though often related to non-cardiac diagnoses.
Why the study?
HFpEF accounts for half of hospitalized heart failure patients, but prevalence estimates vary due to unclear diagnostic criteria.
Population
370 consecutive hospitalized patients admitted with dyspnoea or presumed HF
Comparison
Presumed cardiac vs non-cardiac dyspnoea across contemporary HF subtypes
Design
Prospective observational study
Authors
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HFpEF echo findings in dyspnea warrant diagnostic caution; leaves open whether adjudication refines causal attribution in future cohorts.
Observational (n=370)
Absolute Event Rate: 71% vs 34%
p-value: p=<0.0001
While HFpEF is the most common echocardiographic finding in hospitalized patients with dyspnea and elevated NT-proBNP, it is infrequently the primary adjudicated cause of admission compared to HFrEF.
Nielsen et al. (2019) conducted an observational in Dyspnoea and Heart Failure (n=370). Heart failure with preserved ejection fraction was twice as common in presumptive non-cardiac dyspnea compared to cardiac dyspnea (71% vs 34%, p<0.0001), though often related to non-cardiac diagnoses.
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