Key result
Myocardial virus persistence was associated with significantly impaired endothelial function of the coronary microcirculation compared to patients without virus (ΔCBF 22% vs 110%; P=0.001).
Why the study?
Is myocardial virus persistence and inflammation associated with impaired endothelial function of the coronary microcirculation in patients with nonischemic cardiomyopathy?
Population
71 patients with nonischemic cardiomyopathy, mean age 43+/-13 years, 37 men, 34 women, mean ejection…
Comparison
Myocardial virus persistence and/or myocardial… vs Absence of myocardial virus persistence and/or…
Design
Cross-sectional
Authors
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May indicate viral role in NICM microvascular dysfunction; hypothesis-generating, prospective studies needed before clinical adoption.
Observational (n=71)
Is myocardial virus persistence and inflammation associated with impaired endothelial function of the coronary microcirculation in patients with nonischemic cardiomyopathy?
Absolute Event Rate: 22% vs 110%
p-value: p=0.001
Myocardial virus persistence and inflammation are associated with significant endothelial dysfunction of the coronary microcirculation in patients with nonischemic cardiomyopathy.
Vallbracht et al. (2005) conducted an observational in nonischemic cardiomyopathy (n=71). Myocardial virus persistence vs. No myocardial virus persistence was evaluated on Change in coronary blood flow (ΔCBF) in response to acetylcholine (p=0.001). Myocardial virus persistence was associated with significantly impaired endothelial function of the coronary microcirculation compared to patients without virus (ΔCBF 22% vs 110%; P=0.001).
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