February 1, 1984CirculationOpen Access

Assessment of left ventricular mechanics in patients with asymptomatic aortic regurgitation: a two-dimensional echocardiographic study.

Q: What does this research mean for the field?

Two-dimensional echocardiography combined with cuff blood pressure measurements provides a reliable, noninvasive method to assess left ventricular wall stress and architecture, revealing that asymptomatic patients with severe aortic regurgitation have increased wall stress and altered ventricular geometry despite normal overall contractility. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Can two-dimensional echocardiography combined with cuff blood pressure noninvasively determine left ventricular mechanics and architecture in asymptomatic patients with severe chronic aortic regurgitation?

Population

15 normal subjects and 15 asymptomatic patients with severe chronic aortic regurgitation (total n=30)

Comparison

Two-dimensional echocardiography combined with… vs Normal subjects

Design

Cross-sectional

Authors

MSMartin G. St. John SuttonCardiac Imaging TPTed PlappertUniversity of Pennsylvania JHJohn W. HirshfeldInterventional Cardiology

Discussion

Member takes

Implication

Supports noninvasive detection of afterload excess in asymptomatic AR; leaves open impact on management or intervention timing.

Key Points

This study aims to evaluate left ventricular mechanics in patients with asymptomatic aortic regurgitation using two-dimensional echocardiography.
Assessed wall stress and left ventricular architecture in 15 normal subjects and 15 asymptomatic patients.
Utilized two-dimensional echocardiography and cuff-determined systolic blood pressure values.
Performed load manipulation using sublingual nitroglycerin to evaluate changes post-treatment.
End-systolic meridional stress was significantly higher in patients (113.9 +/- 29 dynes/cm2) compared to normal subjects (85.6 +/- 15.4 dynes/cm2), p < 0.01.
Circumferential wall stress also increased in patients (260 +/- 50.7 dynes/cm2) compared to normals (214.1 +/- 28.4 dynes/cm2), p < 0.01.
Left ventricular mass was greater in patients (227 +/- 60 g) versus normal subjects (130 +/- 22 g), but mass-to-volume ratios and muscle-to-cavity area ratios were significantly lower in patients.

Structured PICO

Population

15 normal subjects and 15 asymptomatic patients with severe chronic aortic regurgitation (total n=30)

Intervention

Two-dimensional echocardiography combined with cuff-determined systolic blood pressure at rest and after sublingual nitroglycerin

Comparator

Normal subjects

Outcome

End-systolic meridional and circumferential wall stress, left ventricular architecture (ratio of muscle to cavity area), and myocardial contractilitysurrogate

Two-dimensional echocardiography can noninvasively detect early afterload excess and altered left ventricular architecture in asymptomatic patients with severe aortic regurgitation despite normal ejection fraction.

Cite This Study

Sutton et al. (1984) studied this question.

synapsesocial.com/papers/6a121e9eea48cb855a343e0d https://doi.org/10.1161/01.cir.69.2.259

Topics

Echocardiography

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Assessment of left ventricular mechanics in patients with asymptomatic aortic regurgitation: a two-dimensional echocardiographic study.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Assessment of left ventricular mechanics in patients with asymptomatic aortic regurgitation: a two-dimensional echocardiographic study.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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