Key result
SLC2A9 AC genotype is linked to more frequent LA dilatation in hypertension and AF.
Why the study?
Uric acid accumulation in cardiomyocytes may cause atrial remodeling, and SLC2A9 gene polymorphisms are a significant risk factor for hyperuricemia.
Does the SLC2A9 gene rs734553 polymorphism affect left atrium diameter in patients with arterial hypertension and atrial fibrillation?
Observational (n=104)
No
Does the SLC2A9 gene rs734553 polymorphism affect left atrium diameter in patients with arterial hypertension and atrial fibrillation?
p-value: p=0.004
The AC genotype of the SLC2A9 gene rs734553 polymorphism is associated with a higher frequency of left atrial dilatation in patients with arterial hypertension and atrial fibrillation.
AC genotype may flag higher LA dilatation risk in hypertensive AF; leaves open whether genotyping aids stratification pending prospective validation.
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Snezhitskiy et al. (2023) conducted an observational in Arterial hypertension and atrial fibrillation (n=104). SLC2A9 gene rs734553 polymorphism vs. AA genotype was evaluated on Frequency of AC genotype in patients with left atrial dilatation (p=0.004). In patients with arterial hypertension and atrial fibrillation, left atrial dilatation was significantly more frequent in those with the AC genotype of the SLC2A9 gene rs734553 polymorphism.
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