In patients with cardiac amyloidosis, congestive heart failure is driven by diastolic dysfunction characterized by thickened ventricular walls and abnormal filling despite preserved systolic function.
May support diastolic dysfunction as HF driver in cardiac amyloidosis; leaves open larger prospective validation.
Seven patients with cardiac amyloidosis were referred to King Khaled University Hospital. All patients in this study developed congestive heart failure. They had a long duration of illness and thickened ventricular wall with marked abnormalities in the left ventricular filling, and normal systolic function. Diastolic function is suggested as a possible mechanism of congestive cardiac failure in the patients presented.
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Nouh et al. (1996) studied this question.
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