Heart rate deceleration and acceleration capacities independently predicted heart failure, with deceleration capacity yielding high diagnostic accuracy in males (AUC 0.88) and females (AUC 0.97).
Case-Control (n=342)
No
Do deceleration and acceleration capacities of heart rate accurately classify heart failure compared to controls?
Deceleration and acceleration capacities of heart rate demonstrate high discriminating performance for classifying heart failure, particularly in females where deceleration capacity outperformed LVEF.
Effect estimate: OR 5.94 (95% CI 1.74-20.25)
p-value: p=0.004
Accurate measurements of autonomic nerve regulation in heart failure (HF) were unresolved. The discriminating performance of deceleration and acceleration capacities of heart rate in HF was evaluated in 130 HF patients and 212 controls. Acceleration capacity and deceleration capacity were independent risk factors for HF in males, evaluated by multiple logistic regression analysis, with odds ratios (ORs) of 5.94 and 0.13, respectively. Acceleration capacity was also an independent risk factor for HF in females, with an OR of 8.58. Deceleration capacity was the best cardiac electrophysiological index to classify HF in males, with an area under the receiver operating characteristic curve (AUC) of 0.88. Deceleration capacity was the best classification factor of HF in females with an AUC of 0.97, significantly higher than even left ventricular ejection fraction (LVEF). Acceleration capacity also showed high performance in classifying HF in males (0.84) and females (0.92). The cut-off values of deceleration capacity for HF classification in males and females were 4.55 ms and 4.85 ms, respectively. The cut-off values of acceleration capacity for HF classification in males and females were -6.15 ms and -5.75 ms, respectively. Our study illustrates the role of acceleration and deceleration capacity measurements in the neuro-pathophysiology of HF.
Hu et al. (Wed,) conducted a case-control in Heart failure (n=342). Deceleration and acceleration capacities of heart rate vs. Healthy controls was evaluated on Heart failure association with acceleration capacity in males (OR 5.94, 95% CI 1.74-20.25, p=0.004). Heart rate deceleration and acceleration capacities independently predicted heart failure, with deceleration capacity yielding high diagnostic accuracy in males (AUC 0.88) and females (AUC 0.97).