Key result
African-American women had the highest rate of annual increase in pulse pressure compared with white men (0.41 mmHg/year greater), while diabetes and obesity strongly affected the rate of change.
Why the study?
What are the determinants of pulse pressure and its annual rate of change in a middle-aged biracial cohort?
Cohort (n=10,071)
Yes
What are the determinants of pulse pressure and its annual rate of change in a middle-aged biracial cohort?
In a middle-aged biracial cohort, pulse pressure increases annually, with the highest rates of increase seen in African-American women, and diabetes and obesity acting as the strongest determinants.
May refine risk stratification by race, sex, and metabolic factors; leaves open causal effects and intervention impacts.
INTRODUCTION: The aim of this study was to examine the effect of vascular and lifestyle risk factors on the annual rate of change in pulse pressure (PP) in a biracial, middle-aged cohort. METHODS AND RESULTS: The study population, drawn from the Atherosclerosis Risk in Communities (ARIC) cohort, included 10, 071 participants, aged 45-64 years at baseline, with a complete set of SBP and DBP readings at each of four visits 3 years apart. The average annual increase in PP was 1.23 mmHg [standard error (SE 0.01], after adjusting for baseline age differences. Compared with white men, African-American women had the highest rate of annual increase in PP (0.41 (SE 0.05) mmHg/year greater) followed by white women [0.23 (SE 0.03) mmHg/year greater] and African-American men [0.19 (SE 0.06) mmHg/year greater]. CONCLUSION: There were significant differences in both average baseline PP and average annual rate of change in PP between men and women and African-Americans and whites. Diabetes and obesity had the strongest effect on the absolute value of baseline PP and the annual rate of change in PP.
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Butler et al. (2015) conducted a cohort in Pulse pressure change (n=10,071). Vascular and lifestyle risk factors (race, sex, diabetes, obesity) vs. White men (for demographic comparisons) was evaluated on Annual rate of change in pulse pressure (PP). African-American women had the highest rate of annual increase in pulse pressure compared with white men (0.41 mmHg/year greater), while diabetes and obesity strongly affected the rate of change.
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