Biomarkers Associated With Pulse Pressure in African-Americans and Non-Hispanic Whites
Population
2,338 individuals (1,193 African-Americans and 1,145 non-Hispanic whites) belonging to hypertensive sibships
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Associations may reflect vascular pathology but should not change practice; leaves open need for outcome studies in hypertension.
Structured PICO
P
Population
2,338 individuals (1,193 African-Americans and 1,145 non-Hispanic whites) belonging to hypertensive sibships
O
Outcome
Association of 47 circulating biomarkers with brachial artery pulse pressuresurrogate
Biomarkers of hemodynamic stress, vascular inflammation, calcification, and matrix remodeling are independently associated with increased pulse pressure, with some ethnic-specific differences.
Cite This Study
Coutinho et al. (2011) studied this question.