Key result
A whole genome scan in African Americans identified two chromosomal regions on chromosomes 1 (LOD = 3.08) and 14 (LOD = 2.42) linked to arterial stiffness, which was 20% heritable.
Population
1251 African Americans in families participating in the HyperGEN study, including children of the…
Design
Cross-sectional
Authors
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Does not yet alter clinical risk stratification; leaves open the identification of specific causal genes driving.
Observational (n=1,251)
Yes
Identified two chromosomal regions (on chromosomes 1 and 14) that likely harbor genes contributing to interindividual variation in arterial stiffness among African Americans.
Sherva et al. (2007) conducted an observational in Hypertension and arterial stiffness (n=1,251). Whole genome scan was evaluated on Arterial stiffness estimated as pulse pressure divided by stroke volume (PP/SV ratio). A whole genome scan in African Americans identified two chromosomal regions on chromosomes 1 (LOD = 3.08) and 14 (LOD = 2.42) linked to arterial stiffness, which was 20% heritable.
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