Genome-Wide Scan for Pulse Pressure in the National Heart, Lung and Blood Institute’s Framingham Heart Study
Population
8,478 members of the National Heart, Lung and Blood Institute's Framingham Heart Study. Pulse pressure…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Does not warrant changes in hypertension care; leaves open validation of linkage regions for vascular stiffness genes.
Structured PICO
P
Population
8,478 members of the National Heart, Lung and Blood Institute's (NHLBI) Framingham Heart Study. Pulse pressure values were available for 6,421 individuals in 1,593 families for heritability estimation and for 2,492 individuals in 330 families for linkage analysis.
O
Outcome
Heritability and chromosomal regions showing evidence of linkage to long-term pulse pressure (PP)surrogate
Pulse pressure has a substantial genetic component with a heritability of approximately 0.52, and several chromosomal regions may harbor genes influencing vascular stiffness.
Cite This Study
DeStefano et al. (2004) studied this question.