Population
46 randomly ascertained families for initial modeling, and a subset of 10 families for 2-point linkage…
Design
Cohort
Authors
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Supports pulse pressure heritability with suggestive linkage to chromosome 21 markers; leaves open replication and causal variant identification before any clinical application.
Pulse pressure demonstrates significant heritability and suggestive genetic linkage to several markers, which are highly correlated with systolic blood pressure.
Atwood et al. (2001) studied this question.
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