Key result
Premature dual anti-platelet therapy interruption is not associated with stent thrombosis in patients treated with the second-generation Resolute zotarolimus-eluting stent.
Why the study?
Does premature DAPT interruption increase the risk of stent thrombosis in patients treated with the Resolute zotarolimus-eluting stent?
Does premature DAPT interruption increase the risk of stent thrombosis in patients treated with the Resolute zotarolimus-eluting stent?
Observational data suggest that premature DAPT interruption may be safe in patients receiving the Resolute zotarolimus-eluting stent, challenging standard guidelines.
Premature DAPT interruption may be safe with Resolute stents; leaves open whether guidelines should change pending randomized data.
Percutaneous coronary intervention is currently the most commonly used revascularization procedure. This success is a direct consequence of the improved medium- and long-term target vessel patency achieved with drug-eluting stents (DES). However, DES are associated with stent thrombosis (ST), a rare but potentially catastrophic complication. Early interruption of dual anti-platelet therapy (DAPT) is a major risk factor for ST and guidelines recommend a minimum duration of DAPT of 6 to 12 months post implantation. Recently published observational data suggest that premature DAPT interruption is not associated with ST in patients treated with the second-generation Resolute zotarolimus-eluting stent. This article reviews the background to the development of Resolute DES and reviews recently published data on ST and DAPT interruption.
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O’Mahony et al. (2014) conducted a review in Percutaneous coronary intervention. Resolute zotarolimus-eluting stent and DAPT interruption was evaluated on Stent thrombosis. Premature dual anti-platelet therapy interruption is not associated with stent thrombosis in patients treated with the second-generation Resolute zotarolimus-eluting stent.
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