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The complete nucleotide sequence of a human beta-actin cDNA was determined, revealing that both the 5' and 3' untranslated regions are highly conserved (>80%) compared to the rat beta-actin gene.
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Enables rodent models for human beta-actin studies; leaves open functional roles in cardiovascular gene regulation.
We report the complete nucleotide sequence of a human beta actin cDNA. Both the 5' and 3' untranslated regions of the sequence are similar (greater than 80%) to the analogous regions of the rat beta-actin gene reported by Nudel et al (1983). When a segment of the 3' untranslated region is used as a radiolabelled probe, strong hybridization to chick beta actin mRNA is seen. This conservation of sequences suggests that strong selective pressures operate on non-translated segments of beta actin mRNA.
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Ponte et al. (1984) studied this question. The complete nucleotide sequence of a human beta-actin cDNA was determined, revealing that both the 5' and 3' untranslated regions are highly conserved (>80%) compared to the rat beta-actin gene.
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