Very low Short Physical Performance Battery scores were associated with a significantly higher risk of incident heart failure (HR 2.22) compared to high scores in older women.
Cohort (n=5,325)
Yes
Does a lower Short Physical Performance Battery (SPPB) score predict incident heart failure in older women without prior heart failure?
Lower physical performance, as measured by the SPPB, is an independent predictor of incident heart failure in older women.
Effect estimate: HR 2.22 (95% CI 1.34-3.66)
Absolute Event Rate: 26% vs 5.6%
p-value: p=<0.001
OBJECTIVE: Reduced functional capacity is a hallmark of early pre-clinical stages of heart failure (HF). The Short Physical Performance Battery (SPPB) is a valid measure of lower extremity physical function, has relatively low implementation burden, and is associated with cardiovascular disease and mortality. However, the SPPB-HF association is understudied in older women among whom HF burden is high. METHODS: = 5325; mean age 79 ± 7 years; 34% Black, 18% Hispanic, and 49% White) without prior HF completed the SPPB consisting of standing balance, strength, and walking tests that were summarized as a composite score from 0 (lowest) to 12 (highest), categorized as very low (0-3), low (4-6), medium (7-9), or high (10-12). Participants were followed for up to 8 years for incident HF (306 cases identified). Cox proportional hazards regression estimated hazard ratios (HR) adjusting for age, race/ethnicity, education, smoking, alcohol, diabetes, hypertension, COPD, osteoarthritis, depression, BMI, systolic blood pressure, lipids, glucose, and accelerometer-measured moderate-vigorous physical activity (MVPA) and sedentary time. RESULTS: -interaction>0.10. CONCLUSION: Lower SPPB scores were associated with greater risk of incident HF in older women even after accounting for differences in HF risk factors and objectively measured PA. Implementing the SPPB in clinical settings could potentially enhance individual-level HF risk assessment, which should be further explored.
Bellettiere et al. (Fri,) conducted a cohort in Incident heart failure (n=5,325). Very low Short Physical Performance Battery (SPPB) score (0-3) vs. High SPPB score (10-12) was evaluated on Incident acute decompensated hospitalized heart failure (HR 2.22, 95% CI 1.34-3.66, p=<0.001). Very low Short Physical Performance Battery scores were associated with a significantly higher risk of incident heart failure (HR 2.22) compared to high scores in older women.