Lower Short Physical Performance Battery scores were significantly associated with higher mortality in heart failure patients (mean SPPB 2.00 in non-survivors vs. 3.48 in survivors; p=0.001).
Cohort (n=175)
Does the Short Physical Performance Battery (SPPB) score predict survival and correlate with clinical and nutritional factors in patients with heart failure?
Lower physical performance, as measured by the SPPB, is significantly associated with increased mortality, poorer nutritional status, and worse renal function in patients with heart failure.
p-value: p=0.001
Abstract Background/Introduction The Short Physical Performance Battery (SPPB) is a well-established and validated tool for assessing lower extremity function. It offers essential insights into frailty, physical performance, and overall prognosis in patients with heart failure. As recognition of functional decline and vulnerability as crucial factors influencing outcomes grows, understanding the clinical factors associated with SPPB scores can improve risk assessment in this group. Purpose To investigate the association between SPPB scores and essential clinical, nutritional, and biochemical characteristics in patients with heart failure, and to evaluate the prognostic significance of SPPB for survival. Methods A total of 175 patients diagnosed with heart failure were evaluated, with a median age of 74 years (range 33–93; 55% male). In addition to the Short Physical Performance Battery (SPPB) assessment, the study gathered data on nutritional status utilizing the Mini Nutritional Assessment (MNA), as well as biomarkers including NT-proBNP and Galectin-3. Renal function parameters, such as creatinine and urea levels, and anthropometric measures, such as age-adjusted body weight and BMI, were also collected. Survival analyses were conducted to compare outcomes based on SPPB score performance. Results The cohort exhibited significantly diminished physical performance, with a median SPPB score of 2 (Interquartile Range 0–4). Higher SPPB scores demonstrated notable positive correlations with improved nutritional status (MNA; rho=0.428, p=0.001), serum albumin levels (rho=0.360, p=0.001), age-adjusted body mass index (BMI; rho=0.228, p=0.026), and body weight (rho=0.170, p=0.024). Conversely, SPPB scores were inversely correlated with NT-proBNP (rho=-0.441, p=0.001), age (rho=-0.337, p=0.001), and serum creatinine levels (rho=-0.153, p=0.046). No significant associations were observed with Galectin-3 or left ventricular ejection fraction. Survival analysis indicated a considerably higher mortality among patients with lower SPPB scores (mean SPPB of 2.00 in non-survivors vs. 3.48 in survivors; p=0.001). Conclusion The Short Physical Performance Battery (SPPB) is a significant, readily implementable metric for assessing physical function in individuals with heart failure. Its robust correlations with nutritional status, renal function, and natriuretic peptide levels emphasize its importance within a comprehensive evaluation of these patients. Significantly, lower SPPB scores have been linked to markedly increased mortality, underscoring the prognostic utility of incorporating physical performance assessments into standard clinical practice.
Novosel et al. (Mon,) conducted a cohort in Congestive heart failure (n=175). Short Physical Performance Battery (SPPB) score vs. Higher SPPB scores was evaluated on Mortality (p=0.001). Lower Short Physical Performance Battery scores were significantly associated with higher mortality in heart failure patients (mean SPPB 2.00 in non-survivors vs. 3.48 in survivors; p=0.001).