Key result
Mild chronic HF is linked to ~62 mm3 hippocampal volume loss without accelerated cognitive decline.
Why the study?
The study was conducted to quantify concurring dynamics affecting total and hippocampal brain volume and cognitive function in patients with chronic HF over three years.
Cohort (n=148)
No
Effect estimate: Mean change -62 mm3 (95% CI -81 to -42)
p-value: p=< 0.0001
In patients with mild stable heart failure, despite reduced baseline hippocampal volume, there is no accelerated cognitive decline or brain atrophy over a 3-year period compared to normal aging.
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No accelerated cognitive decline in mild stable HF; leaves open causality and longer-term effects.
Frey et al. (2021) conducted a cohort in chronic heart failure (HF) (n=148). Mild chronic heart failure was associated with a small 3-year progressive hippocampal volume loss (-62 mm3; 95% CI -81 to -42; P<0.0001), without accelerated deterioration in cognitive function.
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