Key result
Heart failure patients without clinical dementia exhibited significantly greater local atrophy in the parahippocampal gyrus compared to controls (Z-score 1.12 vs 0.63; P=0.002).
Population
37 participants: 20 stable heart failure patients without clinical dementia, and 17 controls.
Design
Case-control
Authors
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HF patients without dementia show parahippocampal atrophy that may signal early cognitive vulnerability; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=37)
Absolute Event Rate: 1.12% vs 0.63%
p-value: p=0.002
Heart failure patients without clinical dementia exhibit prominent local atrophy in the parahippocampal gyrus, indicating a potential structural brain risk for developing cognitive impairment.
Meguro et al. (2017) conducted a case-control in Heart Failure without Dementia (n=37). Heart failure vs. Controls without heart failure was evaluated on Severity of atrophy in the parahippocampal gyrus (Z-score) (p=0.002). Heart failure patients without clinical dementia exhibited significantly greater local atrophy in the parahippocampal gyrus compared to controls (Z-score 1.12 vs 0.63; P=0.002).
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