What does this research mean for the field?

Co-administration of an angiotensin II receptor antagonist and an angiotensin-converting enzyme inhibitor produces synergistic antihypertensive effects and prevents the partial escape associated with chronic ACE inhibitor monotherapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1998Journal of Hypertension

Synergistic effects of combined converting enzyme inhibition and angiotensin II antagonism on blood pressure in conscious telemetered spontaneously hypertensive rats

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Why the study?

Does combined administration of valsartan and benazeprilat reduce blood pressure more effectively than monotherapy in spontaneously hypertensive rats?

Population

Conscious telemetered spontaneously hypertensive rats

Comparison

Combined administration of valsartan and… vs Monotherapy with valsartan or benazeprilat

Design

Preclinical

Follow-up

2 weeks

Authors

RWRandy L. WebbNovartis (United States)ANAida E. NavarreteMartin Luther University Halle-Wittenberg SDScott L. DavisBrigham Young University–Hawaii

Discussion

Member takes

Implication

Hypothesis-generating for dual ACEI/ARB synergy; leaves open translation to human hypertension.

Structured PICO

Does combined administration of valsartan and benazeprilat reduce blood pressure more effectively than monotherapy in spontaneously hypertensive rats?

Population

Conscious telemetered spontaneously hypertensive rats

Intervention

Combined administration of valsartan and benazeprilat (0.5-10 mg/kg per day each) via 2-week infusions

Comparator

Monotherapy with valsartan or benazeprilat (0.5-10 mg/kg per day)

Outcome

Blood pressure and heart ratesurrogate

Combined ACE inhibitor and ARB therapy produces a synergistic antihypertensive effect in spontaneously hypertensive rats compared to monotherapy.

Cite This Study

Webb et al. (1998) studied this question.

synapsesocial.com/papers/6a12eaa083732aa7db9e8dbc https://doi.org/10.1097/00004872-199816060-00016

Topics

Hypertension management

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Synergistic effects of combined converting enzyme inhibition and angiotensin II antagonism on blood pressure in conscious telemetered spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Synergistic effects of combined converting enzyme inhibition and angiotensin II antagonism on blood pressure in conscious telemetered spontaneously hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider