Key result
Aortic annular plane systolic excursion was lower in cats with hypertrophic cardiomyopathy compared to normal cats.
Why the study?
Impairment of LV longitudinal function is an early marker of systolic dysfunction in HCM, but aortic annular plane systolic excursion has not been evaluated in cats.
Does Aortic annular plane systolic excursion (AAPSE) differ between normal cats and cats with hypertrophic cardiomyopathy (HCM)?
Case-Control (n=175)
Yes
Does Aortic annular plane systolic excursion (AAPSE) differ between normal cats and cats with hypertrophic cardiomyopathy (HCM)?
Aortic annular plane systolic excursion is lower in cats with hypertrophic cardiomyopathy, particularly in stage C, and may serve as a useful echocardiographic marker of LV systolic performance.
Answers are grounded in this paper and cite their sources.
AAPSE was lower in cats with HCM; supports its evaluation as an LV systolic marker but leaves utility unproven pending prospective studies.
BACKGROUND: Impairment of left ventricular (LV) longitudinal function is an early marker of systolic dysfunction in hypertrophic cardiomyopathy (HCM). Aortic annular plane systolic excursion (AAPSE) is a measure of LV longitudinal function in people that has not been evaluated in cats. HYPOTHESIS: Aortic annular plane systolic excursion is lower in cats with HCM compared to control cats, and cats in stage C have the lowest AAPSE. ANIMALS: One hundred seventy-five cats: 60 normal, 61 HCM stage B and 54 HCM stage C cats. MATERIALS: Multicenter retrospective case-control study. Electronic medical records from 4 referral hospitals were reviewed for cats diagnosed with HCM and normal cats. HCM was defined as LV wall thickness ≥6 mm and normal cats ≤5 mm. M-mode bisecting the aorta in right parasternal short-axis view was used to measure AAPSE. RESULTS: Aortic annular plane systolic excursion was lower in HCM cats compared to normal cats (3.9 ± 0.9 mm versus 4.6 ± 0.9 mm, P < .001) and was lowest in HCM stage C (2.4 ± 0.6 mm, P < .001). An AAPSE <2.9 mm gave a sensitivity of 83% (95% CI 71%-91%) and specificity of 92% (95% CI 82%-97%) to differentiate HCM stage C from stage B. AAPSE correlated with mitral annular plane systolic excursion (r = .6 [.4-.7], P < .001), and atrial fractional shortening (r = .6 [.5-.7], P < .001), but showed no correlation with LV fractional shortening. CONCLUSIONS AND CLINICAL IMPORTANCE: Aortic annular plane systolic excursion is an easily acquired echocardiographic variable and might be a new measurement of LV systolic performance in cats with HCM.
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Dutton et al. (2023) conducted a case-control in Hypertrophic cardiomyopathy (n=175). Aortic annular plane systolic excursion (AAPSE) measurement vs. Normal cats was evaluated on Aortic annular plane systolic excursion (AAPSE) (p=<.001). Aortic annular plane systolic excursion was lower in cats with hypertrophic cardiomyopathy compared to normal cats.
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