Key result
Muscarinic receptor stimulation with carbachol protected isolated rat myocardium from noradrenaline-induced damage, reducing creatine kinase release without decreasing contractility.
Why the study?
Does muscarinic receptor stimulation with carbachol reduce noradrenaline-induced myocardial damage in isolated perfused rat hearts?
Population
Isolated anterogradely perfused rat hearts
Comparison
Carbachol (3 x 10-10 mol l-1) with or without… vs Noradrenaline 10(-6) mol l-1 alone for 45 min
Design
Preclinical
Follow-up
45 min
Authors
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Should not yet alter clinical management of catecholamine injury; leaves open translation of muscarinic protection to human myocardium.
Does muscarinic receptor stimulation with carbachol reduce noradrenaline-induced myocardial damage in isolated perfused rat hearts?
Muscarinic receptor stimulation protects isolated rat myocardium from catecholamine-induced damage without compromising contractility.
Waldenström et al. (1994) studied Catecholamine-induced myocardial damage. Carbachol (muscarinic receptor stimulation) plus noradrenaline vs. Noradrenaline alone was evaluated on Release of creatine kinase to the perfusion buffer. Muscarinic receptor stimulation with carbachol protected isolated rat myocardium from noradrenaline-induced damage, reducing creatine kinase release without decreasing contractility.
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